A Path to Prediction of Outcomes in Juvenile Idiopathic Inflammatory Myopathy
Identifieur interne : 000B44 ( Main/Exploration ); précédent : 000B43; suivant : 000B45A Path to Prediction of Outcomes in Juvenile Idiopathic Inflammatory Myopathy
Auteurs : Ann Marie Reed [États-Unis] ; Cynthia S. Crowson [États-Unis] ; Jeffrey Arthur Dvergsten [États-Unis]Source :
- Frontiers in Immunology [ 1664-3224 ] ; 2019.
Abstract
Humans have an innate desire to observe and subsequently dissect an event into component pieces in an effort to better characterize the event. We then examine these pieces individually and in combinations using this information to determine the outcome of future similar events and the likelihood of their recurrence. Practically, this attempt to foretell an occurrence and predict its outcomes is evident in multiple disciplines ranging from meteorology to sociologic studies. In this manuscript we share the historical and present-day tools to predict course and outcome in juvenile idiopathic inflammatory myopathy including clinical features, testing, and biomarkers. Further we discuss considerations for building more complex predictive models of outcome especially in diseases such as juvenile idiopathic inflammatory myopathy where patients numbers are low. Many of the barriers to developing risk prediction models for juvenile idiopathic inflammatory myopathy outcomes have improved with many remaining challenges being addressed.
Url:
DOI: 10.3389/fimmu.2019.00638
PubMed: 31001260
PubMed Central: 6454149
Affiliations:
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Crowson</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Mayo Clinic</institution>,<addr-line>Rochester, MN</addr-line>,<country>United States</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dvergsten, Jeffrey Arthur" sort="Dvergsten, Jeffrey Arthur" uniqKey="Dvergsten J" first="Jeffrey Arthur" last="Dvergsten">Jeffrey Arthur Dvergsten</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Division of Pediatric Rheumatology, Department of Pediatrics, Duke University</institution>,<addr-line>Durham, NC</addr-line>,<country>United States</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Immunology</title><idno type="eISSN">1664-3224</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Humans have an innate desire to observe and subsequently dissect an event into component pieces in an effort to better characterize the event. We then examine these pieces individually and in combinations using this information to determine the outcome of future similar events and the likelihood of their recurrence. Practically, this attempt to foretell an occurrence and predict its outcomes is evident in multiple disciplines ranging from meteorology to sociologic studies. In this manuscript we share the historical and present-day tools to predict course and outcome in juvenile idiopathic inflammatory myopathy including clinical features, testing, and biomarkers. Further we discuss considerations for building more complex predictive models of outcome especially in diseases such as juvenile idiopathic inflammatory myopathy where patients numbers are low. Many of the barriers to developing risk prediction models for juvenile idiopathic inflammatory myopathy outcomes have improved with many remaining challenges being addressed.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Kleisiaris, Cf" uniqKey="Kleisiaris C">CF Kleisiaris</name></author><author><name sortKey="Sfakianakis, C" uniqKey="Sfakianakis C">C Sfakianakis</name></author><author><name sortKey="Papathanasiou, Iv" uniqKey="Papathanasiou I">IV Papathanasiou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Steyerberg, Ew" uniqKey="Steyerberg E">EW Steyerberg</name></author><author><name sortKey="Moons, Kg" uniqKey="Moons K">KG Moons</name></author><author><name sortKey="Van Der Windt, Da" uniqKey="Van Der Windt D">DA van der Windt</name></author><author><name sortKey="Hayden, Ja" uniqKey="Hayden J">JA Hayden</name></author><author><name sortKey="Perel, P" uniqKey="Perel P">P 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uniqKey="Reed A">AM Reed</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aggarwal, R" uniqKey="Aggarwal R">R Aggarwal</name></author><author><name sortKey="Bandos, A" uniqKey="Bandos A">A Bandos</name></author><author><name sortKey="Reed, Am" uniqKey="Reed A">AM Reed</name></author><author><name sortKey="Ascherman, Dp" uniqKey="Ascherman D">DP Ascherman</name></author><author><name sortKey="Barohn, Rj" uniqKey="Barohn R">RJ Barohn</name></author><author><name sortKey="Feldman, Bm" uniqKey="Feldman B">BM Feldman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Olazagasti, J" uniqKey="Olazagasti J">J Olazagasti</name></author><author><name sortKey="Crowson, C" uniqKey="Crowson C">C Crowson</name></author><author><name sortKey="Hein, M" uniqKey="Hein M">M Hein</name></author><author><name sortKey="De Padilla, C" uniqKey="De Padilla C">C de Padilla</name></author><author><name sortKey="Aggarwal, R" uniqKey="Aggarwal R">R Aggarwal</name></author><author><name sortKey="Oddis, C" uniqKey="Oddis C">C Oddis</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Reed, Ann Marie" sort="Reed, Ann Marie" uniqKey="Reed A" first="Ann Marie" last="Reed">Ann Marie Reed</name></noRegion><name sortKey="Crowson, Cynthia S" sort="Crowson, Cynthia S" uniqKey="Crowson C" first="Cynthia S." last="Crowson">Cynthia S. Crowson</name><name sortKey="Dvergsten, Jeffrey Arthur" sort="Dvergsten, Jeffrey Arthur" uniqKey="Dvergsten J" first="Jeffrey Arthur" last="Dvergsten">Jeffrey Arthur Dvergsten</name><name sortKey="Reed, Ann Marie" sort="Reed, Ann Marie" uniqKey="Reed A" first="Ann Marie" last="Reed">Ann Marie Reed</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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